Adaptive nonparametric detection in cryo-electron
Mikhail Langovoy, Michael Habeck and Bernhard Schölkopf
In: 58th World Statistics Congress of the International Statistical Institute (ISI 2011)(2011).
Cryo-electron microscopy (cryo-EM) is an emerging experimental method to characterize the structure of large biomolecular assemblies. Single particle cryo-EM records 2D images (so-called micrographs) of projections of the three-dimensional particle, which need to be processed to obtain the threedimensional reconstruction. A crucial step in the reconstruction process is particle picking which
involves detection of particles in noisy 2D micrographs with low signal-to-noise ratios of typically 1:10
or even lower. Typically, each picture contains a large number of particles, and particles have unknown
irregular and nonconvex shapes.