Numerical characterizations of DNA sequences based on the graphical representations
Janez Žerovnik and Igor Pesek
In: Mathematical methods and modelling for students of chemistry and biology : proceedings of the conference "Mathematical Methods in Chemistry", September 22-24, 2007, Split, Croatia.

Abstract

Nowadays the automated DNA sequences techniques have led to an explosive growth of the number and the length of DNAs sequences from different organisms. This has resulted in a large accumulation of data in the DNA databases, but has also called for the development of suitable techniques for rapid viewing and analysis of the data. Graphical representations of DNA sequences were initiated by Hamori and later expanded by many others. The advantage of graphical representation of DNA sequences is that they allow visual inspection of data, helping and recognizing major differences among similar DNA sequences. These techniques provide useful insights into local and global characteristics and the occurrences, variations and repetition of the nucleotides along a sequence which are not as easily obtainable by other methods. Since there are some drawbacks of such techniques, Randić et al. extended it even further with the use of numerical descriptors which they derive from the graphical representation.

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