PASCAL - Pattern Analysis, Statistical Modelling and Computational Learning

Comparing early and late data fusion methods for gene function prediction
Matteo Re and Giorgio Valentini
In: Neural Nets WIRN09 (2009) IOS Press , pp. 197-207. ISBN 978-1-60750-072-8

Abstract

High-throughput biotechnologies are playing an increasingly important role in biomolecular research. Their ability to provide genome wide views of molecular mechanisms occurring in living cells could play a crucial role in the elucidation of biomolecular processes at system level but dataset produced using these techniques are often high-dimensional and very noisy making their analysis challenging because the need to extract relevant information from a sea of noise. Gene function prediction is a central problem in modern bioinformatics and recent works pointed out that gene function prediction performances can be improved by integrating heterogeneous biomolecular data sources. In this contribution we compared performances achievable in gene function prediction by early and late data fusion methods. Given that, among the available late fusion methods, ensemble systems have not been, at today, extensively investigated, all the late fusion experiments were performed using multiple classifier systems.\newline Experimental results show that late fusion of heterogeneous datasets realized by mean of ensemble systems outperformed both early fusion approaches and base learners trained on single types of biomolecular data.

EPrint Type:Book Section
Project Keyword:Project Keyword UNSPECIFIED
Subjects:Multimodal Integration
ID Code:6544
Deposited By:Giorgio Valentini
Deposited On:08 March 2010