PASCAL - Pattern Analysis, Statistical Modelling and Computational Learning

Bayesian Joint Estimation of CN and LOH Aberrations
Marcus Hutter
In: 3rd International Workshop on Practical Applications of Computational Biology and Bioinformatics, 10-12 June 2009, Spain.


SNP-microarrays are able to measure simultaneously both copy number and genotype at several single nucleotide polymorphism positions. Combining the two data, it is possible to better identify genomic aberrations. For this purpose, we propose a Bayesian piecewise constant regression which infers the type of aberration occurred, taking into account all the possible influence in the microarray detection of the genotype, resulting from an altered copy number level. Namely, we model the distributions of the detected genotype given a specific genomic alteration and we estimate the hyper-parameters used on public reference datasets.

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EPrint Type:Conference or Workshop Item (Paper)
Project Keyword:Project Keyword UNSPECIFIED
Subjects:Computational, Information-Theoretic Learning with Statistics
ID Code:5843
Deposited By:Marcus Hutter
Deposited On:08 March 2010