PASCAL - Pattern Analysis, Statistical Modelling and Computational Learning

Estimation of the PCR efficiency based on a size-dependent modelling of the amplification process
Nadia Lalam, Christine Jacob and Peter Jagers
C. R. Acad. Sci. Paris, Ser. I Volume 341, Number 10, pp. 631-634, 2005. ISSN 1636-073X

Abstract

We propose a stochastic modelling of the PCR amplification process by a size-dependent branching process starting as a supercritical Bienaymé-Galton-Watson transient phase and then having a saturation near-critical size-dependent phase. This model based on the concept of saturation allows one to estimate the probability of replication of a DNA molecule at each cycle of a single PCR trajectory with a very good accuracy.

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
EPrint Type:Article
Project Keyword:Project Keyword UNSPECIFIED
Subjects:Learning/Statistics & Optimisation
ID Code:1466
Deposited By:Nadia Lalam
Deposited On:28 November 2005